Disclosed are Agonists and Antagonists of bombesin which are derivatives of naturally occuring bombesin possessing modified derivatives of phenylalanine.
The invention relates to novel bombesin derivatives (see for example, figure 2) which act as bombesin receptor antagonists by blocking the binding of bombesin, GRP or related peptides to cellular receptors.
The present invention encompasses novel peptides that are antagonists to bombesin and bombesin like peptides and are useful in the treatment of cancer.
Disclosed are Agonists and Antagonist of bombesin which are derivatives of naturally occurring bombesin possessing a methyl sulfide or a methyl amide bond connecting the two amino acids on the carboxy terminal end.
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3).
Pure nucleic acids encoding novel receptors for bombesin-like peptides, the novel receptors themselves, and their antibodies.
A rat bombesin receptor subtype-3 has been isolated, cloned and sequenced.
A rhesus monkey bombesin receptor subtype-3 has been isolated, cloned and sequenced.
The peptide (1) binds to the bombesin receptor (4) and has an 11C carbon atom.
The invention is directed to novel Lutetium-177-labeled bombesin analogs for treatment of tumor by radiotherapy.
Bombesin receptor antagonists have been found to be useful in the treatment of sexual dysfunction in both males and females.
Treatment comprises administering to a patient in need thereof, an effective amount of a bombesin analog.
Also described is a radiopharmacon for localizing a tumour (18) which expresses a bombesin receptor (4).
Such compounds may be used in the treatment of conditions that result from deregulated expression of bombesin receptor subtype-3.
This comprises a peptide (1) which binds to the bombesin receptor (4) and has an 11C carbon atom.
A method of treating liver cancer involving administration to the subject a therapeutically effective amount of a bombesin analog.
Bombesin receptor antagonists have been found to be useful in the treatment of sexual dysfunction in both males and females.
Such compounds may be used in the treatment of conditions that result from deregulated expression of bombesin receptor subtype-3.
A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed.
The use of a peptide (1) for producing an agent for detecting a tumour (18) which expresses a bombesin receptor (4) is described.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Traduction Translation Traducción Übersetzung Tradução Traduzione Traducere Vertaling Tłumaczenie Mετάφραση Oversættelse Översättning Käännös Aistriúchán Traduzzjoni Prevajanje Vertimas Tõlge Preklad Fordítás Tulkojumi Превод Překlad Prijevod 翻訳 번역 翻译 Перевод