Aberrant sporogonic development of dmc1 (a meiotic recombinase) deficient plasmodium berghei parasites. plos one... PbDmc1 KO parasites were shown to be approximately 18 times more sensitive to Bizelesin, a DNA alkylating drug compared to WT parasites as reflected by impairment of oocyst formation and sporogonic development in the mosquito vector....
Matrix attachment region (mar) properties and abnormal expansion of at island minisatellites in fra16b fragile sites in leukemic cem cellsAT-rich minisatellites (AT islands) are sites of genomic instability in cancer cells and targets for extremely lethal AT-specific drugs, such as bizelesin....
© 2003 european society for medical oncology a phase i study of bizelesin, a highly potent and selective dna- interactive agent, in patients with advanced solid malignanciesBackground: The aim of this study was to assess the feasibility of administering bizelesin, a cyclopropyl-pyrroloindole with extraordinarily high potency as a bifunctional DNA-damaging agent and selectivity for specific AT-rich DNA sequences, as a single i.v....
The dna minor groove-alkylating cyclopropylpyrroloindole drugs adozelesin and bizelesin induce different dna damage response pathways in human colonAs members of the cyclopropylpyrroloindole family, adozelesin and bizelesin cause genomic DNA lesions by alkylating DNA....
