The prostaglandin f synthase activity of the human aldose reductase akr1b1 brings new lenses to look at pathologic conditions... We also show that AKR1B1 is able to regulate PGE2 production through PGF2α acting on its FP receptor and that aldose reductase inhibitors like alrestatin, Statil (ponalrestat), and EBPC exhibit distinct and characteristic inhibition of PGF2α production in different cell models....
Activated and unactivated forms of human erythrocyte aldose reductase.... The unactivated enzyme was strongly inhibited by aldose reductase inhibitors such as sorbinil, alrestatin, and quercetrin, and by phosphorylated intermediates such as ADP, glycerate 3-phosphate, glycerate 1,3-bisphosphate, and glycerate 2,3-trisphosphate....
Atom-precisemodification of silver(i) thiolate clusterby shell ligand substitution: a new approach to generation of clusterfunctionality and chirality... The fluorescence and electrochemicalactivity of the postmodified Ag20 clusters can be modulatedby alrestatin or ferrocenecarboxylic acid substitution....
Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophysiological study.The efficacy of treatment with an aldose reductase inhibitor (1,3-dioxo-1 H-benz-de-isoquinoline-2(3H)-acetic acid, AY-22,284, Alrestatin) on peripheral nerve function in diabetic polyneuropathy was assessed....
