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Identification and mechanistic study of novel drug metabolites by lc-ms....screens.This thesis investigates Fenclozic acid, homopiperazine reactivity, homomorphyline reactive aldehyde and methanol adduct formation, where RMs were not detected through routine glutathione/cyanide trapping...
général - core.ac.uk - PDF: shura.shu.ac.uk
Significantly different covalentbinding of oxidativemetabolites, acyl glucuronides, and s‑acyl coa conjugates formed from xenobiotic carboxylic acidsin human liver microsomes... While ibuprofenand tolmetin are still on the market, ibufenac, fenclozic acid, tienilicacid, suprofen, and zomepirac were stopped before their launch orwithdrawn....
Identification of the reactive metabolites of fenclozic acid in bile duct cannulatedratsFenclozic acid (Myalex) was developedby ICI pharmaceuticals inthe 1960s for the treatment of rheumatoid arthritis and was a promisingcompound with a good preclinical safety profile...
The pharmacology of fenclozic acid (2-(4-chlorophenyl)thiazol-4-ylacetic acid; i.c.i. 54,450; 'myalex'); a new compound with anti-inflammatory, analgesic and antipyretic activity... Fenclozic acid (2-(4-chlorophenyl)thiazol-4-ylacetic acid; I.C.I....

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