Resolution of pharmaceuticals via crystallization on chemically modified surfaces... Racemic compounds being investigated include the antibiotic 3-phenyllactic acid(3PLA) and the muscle-tissue repairing amino acid N-acetylleucine(NAL)....
Synthesis of (r)-(-)- and (s)-(+)-4-fluorodeprenyl and (r)-(-)- and (s)-(+)-[n-11c-methyl]-4-fluorodeprenyl and positron emission tomography studies in baboon brain....4-fluorobenzaldehyde with nitroethane followed by reduction with lithium aluminum hydride to produce racemic 4-fluoroamphetamine, which was resolved by recrystallization with L- or D-N-acetylleucine to yield (R)-(-)-4-fluoroamphetamine or (S)-(+)-4-fluoroamphetamine in greater than 96% enantiomeric excesses and in yields of 42 and 39%, respectively....
Characterization of the conglomerate form of acetyl-dl-leucine by thermal analysis and solubility measurements... In order to determine which type of crystal is obtained in the case of acetylleucine, an active pharmaceutical ingredient (API), analytical methods have been used to partially elucidate the binary and ternary phase diagrams of the system composed...
