Growth inhibitory effects of antifolates against an adriamycin-resistant human small cell lung cancer cell line... Furthermore, this cell line was found to have no cross-resistance to edatrexate and minimal cross-resistance to trimetrexate, 254-S (cisplatin analog), 5-fluorouracil and 4-hydroperoxyifosfamide....
Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo...(MFR) were studied in vitro and in vivo toassess the dynamics of membrane transport of two categoriesantifolates; folate-based inhibitors of dihydrofolatereductase (methotrexate, edatrexate, aminopterin, PT523,and PT644) and thymidylate synthase (TS) [CB3717, raltitrexed,plevitrexed (BGC9331), pemetrexed andGW1843]....
Effect of vehicles and penetration enhancers on the in vitro and in vivo percutaneous absorption of methotrexate and edatrexate through hairless mouse skin... The objective of this study was to determine the effect of vehicles and penetration enhancers on the percutaneous absorption of MTX and its analog edatrexate (EDAM), and develop transdermal (TD) delivery systems of the drugs for the treatment of RA
Original article evaluation of dose-intense ifosfamide, with and without edatrexate, in adults with sarcoma... To de ® ne the maximally tolerated dose (MTD) of ifosfamide when given with G-CSF on an every other week schedule, and to de ® ne the MTD of edatrexate that can be given every two weeks with an intense schedule of ifosfamide....
