Cardiotonic actions of selective phosphodiesterase inhibitors in rat isolated ventricular cardiomyocytes.... The contractile effects of the novel cardiotonic agent HN-10200 (2-[3-methoxy-5-methylsulphinyl-2-thienyl]-1H-imidazo-[4,5-c]-p yri dine hydrochloride), were examined and comparisons made with the responses obtained to a structurally similar compound, sulmazole, and to a number of other compounds which are known to inhibit phosphodiesterase (PDE) isoenzymes with differing selectivities; namely, enoximone (PDE III inhibitor),...
Molecular pharmacology, 34:761-768 the new positive inotrope sulmazole inhibits the function of guanine nucleotide regulatory proteins by affecting gtp turnoverThe effect of the new cardiotonic agent sulmazole on the guanine nucleotide regulatory protein-adenylate cyclase system was studied in rat adipocyte membranes....
A comparative study of the cardiovascular and biochemical actions of the imidazo [4,5b] pyridine sulmazole and an imidazo [4,5c] pyridine analogue, bw a746c.... BW A746C is a chemical analogue of the imidazo [4,5b] pyridine, sulmazole (AR-L115 BS)....
Activation of the sheep cardiac sarcoplasmic reticulum ca(2+)-release channel by analogues of sulmazole.... The effect of sulmazole and several structurally related analogues on cardiac sarcoplasmic reticulum (SR) Ca(2+)-release channel gating and on [3H]-ryanodine binding to isolated SR membrane...
