903-8 mitogenic effect of thromboxane a2and its synergistic interaction with serotonin on smooth muscle cell proliferation is reversed by ridogrel ...injury.PurposeIn this study, we examined whether ridogrel (a TxA2synthase inhibitor/receptor antagonist) can inhibit the TxA2induced SMC proliferation both in the presence and absence of 5HT.MethodsCanine...
Thromboxane a2 receptor antagonism and synthase inhibition in essential hypertensionShort-term effects of ridogrel, a combined thromboxane synthase inhibitor and receptor antagonist, were investigated in 16 patients with uncomplicated essential hypertension....
Combined thromboxane a2synthase inhibition and prostaglandin endoperoxide receptor antagonism limits myocardial infarct size after mechanical coronary occlusion and reperfusion at doses enhancing coronary thrombolysis by streptokinase ... Coronary thrombi, induced by crush injury and stenosis of the coronary artery, were lysed with streptokinase, 10,000 IU/kg body weight over 90 min, in dogs receiving solvent (n = 11), ridogrel, 0.31...
Efficacy and safety of oral ridogrel in the treatment of ulcerative colitis: two multicentre, randomized, double-blind studiesBackground: Ridogrel at low doses inhibits thromboxane synthase....
