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Application of the guanidine–acylguanidine bioisosteric approach to npy y2 receptor antagonists: bivalent, radiolabeled and fluorescent pharmacological tools...(S)-3.48 with succinimidyl [2,3-3H]-propionate afforded the easily accessible, highly potent and selective tritiated Y2R antagonist [3H]-UR-PLN196 (A2: 43 nM, Ca2+ assay; KD: 43 nM, determined by kinetic studies), which was shown to be useful for the quantification of Y2R binding sites and for the radiochemical determination of Y2R binding affinities of small molecules....
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Adenine nucleotide storage and secretion in platelets as studied by 31p nuclear magnetic resonance....145.7 MHz and by chemical and radiochemical determination of nucleotide levels....


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