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pinacidil

santé / chimie - iate.europa.eu

The invention discloses a novel process for preparing pinacidil i.e. N''-cyano-N'-(4-pyridyl)-N-(1,2,2-trimethylpropyl)-guanidine of formula (I), having hypotensive activity.

L'invention se rapporte à un nouveau procédé de préparation de pinacidile, c'est-à-dire N''-cyano-N'-(4-pyridyl)-N-(1,2,2-triméthylpropyl)-guanidine de la formule (I), ayant une activité hypotensive.

chimie - wipo.int

The use of nicorandil or pinacidil or a pharmaceutically acceptable salt or a hydrate thereof in the preparation of a medicament for the treatment of peripheral vascular disease.

Utilisation de nicorandile et de pinacidile ou d'un de leurs sels ou d'hydrates pharmaceutiquement acceptables dans la préparation d'un médicament pour le traitement des maladies vasculaires périphériques.

santé - wipo.int

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Multiple actions of pinacidil on adenosine triphosphate-sensitive potassium channels in guinea-pig ventricular myocytes.... The patch-clamp method was used to study the effects of pinacidil on the adenosine 5'-triphosphate (ATP)-sensitive K+ channel current in guinea-pig ventricular myocytes....

général - core.ac.uk - PDF: www.pubmedcentral.nih.gov

No deterioration of insulin secretion by the potassium channel opener pinacidil in essential hypertension... The potassium channel opener pinacidil has antihypertensive properties....

PDF: www.loc.gov

Evidence that the mechanism of the inhibitory action of pinacidil in rat and guinea-pig smooth muscle differs from that of glyceryl trinitrate.The effects of pinacidil have been compared with those of glyceryl trinitrate (GTN) using the aorta and portal vein of the rat and the trachealis and taenia caeci of the guinea-pig....

PDF: www.pubmedcentral.nih.gov

The k+ channel opener pinacidil in hypertension - effect on glucose-tolerance and insulin-secretion... Pinacidil exerts an anti-hypertensive action by opening the so-called ATP-sensitive potassium channels in vascular smooth muscle cells, Since pinacidil has been shown to inhibit...

PDF: www.loc.gov

Serum concentrations and urinary excretion of pinacidil and its major metabolite, pinacidil pyridine-n-oxide following i.v. and oral administration in healthy volunteers.Serum concentrations of pinacidil and its major metabolite pinacidil pyridine-N-oxide were determined following administration of both an intravenous solution and a sustained release oral preparation...

PDF: www.pubmedcentral.nih.gov

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