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nafazatrom

nafazatrom

santé / chimie - iate.europa.eu
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Interference with tumor cell-induced degradation of endothelia~ matrix on the antimetastatic action of nafazatrom 1,2ABSTRACT-The antithrombotic compound nafazatrom was eval-uated in several in vivo and in vitro assays to elucidate the mechanism of its antimetastatic activity...
santé - core.ac.uk - PDF: jnci.oxfordjournals.org

Publications scientifiques

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Beneficial effects of nafazatrom on ischemic reperfused myocardiumThe effect of nafazatrom, a new antithrombotic agent, was studied in a canine model of regional myocardial ischemia...
général - core.ac.uk - PDF: www.ncbi.nlm.nih.gov
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Effect of nafazatrom and indomethacin on pulmonary removal of prostaglandin e1 after endotoxin in rabbits.1 We compared the effects of endotoxin on pulmonary prostaglandin E1 (PGE1) removal in groups of rabbits pretreated with the cyclo-oxygenase inhibitor, indomethacin, or nafazatrom (Bay g 6575), which has been shown to increase plasma prostacyclin concentrations...
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov
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Survival of mice with nc carcinoma is unchanged by drugs that are thought to inhibit thromboxane synthesis or increase prostacyclin formation.Mice transplanted with NC carcinoma were treated with the thromboxane synthetase inhibitor dazmegrel (UK38485) or with nafazatrom (BAY G 6575), a compound that is reported to increase prostacyclin formation...
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov
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Role of lipoxygenase products in murine pulmonary granuloma formation.... The development of hypersensitivity-type pulmonary granulomas in mice was dramatically suppressed by inhibitors with anti-LO activity (nordihydroguairetic acid (NDGA), nafazatrom, and BW755c) in a dose-dependent manner, while indomethacin, which is primarily CO-selective, had no significant effect...
général - core.ac.uk - PDF: www.pubmedcentral.nih.gov


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