Alpha1-adrenoceptor-mediated phosphorylation of myosin in rat-tail arterial smooth muscle.... Muscle strips with the endothelium removed contracted in response to the alpha1-adrenoceptor agonist cirazoline, with half-maximal contraction at 0.23...
Stimulation or blockade of α1-adrenergic receptors does no affect hippocampal precursor activity or neurogenesis.(A) Treatment of adult hippocampal cells with norepinephrine (NE) leads to 2-fold increase in neurosphere numbers, however, treatment with cirazoline or prazosin does not affect neurosphere formation at any dose (n = 4 experiments)....
Selectivity of the imidazoline alpha-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned alpha 1-adrenoceptor subtypes.... To investigate the structure-activity relationships of alpha-adrenoceptor agonists for the alpha 1-adrenoceptor subtypes, we have compared the imidazoline class of compounds, oxymetazoline and cirazoline, with the phenethylamine, noradrenaline, in their affinities and also in their intrinsic activities in Chinese hamster ovary (CHO) cells stably expressing the cloned...
Relationship between alpha adrenoceptor occupancy and response for the alpha-i adrenoceptor agonist, cirazoline, andThe relationship between alpha adrenoceptor occupancy and response was investigated for the alpha-i adrenoceptor agonist, cirazoline, and the alpha-2 adrenoceptor agonist, B-HT 933, in canine saphenous vein, a tissue known to contain both alpha adrenoceptor subtypes....
