Relationship between the pharmacological activity of antitumor drugs ametantrone and mitoxantrone (novatrone) and their ability to condense nucleic acids.Ametantrone (HAQ) and mitoxantrone (DHAQ) are structurally similar antitumor drugs of the anthracenedione class....
Anthracenedione antineoplastic agent effects on drug metabolism in vitro and in vivo: relationship between structure and mechanism of inhibition. kharasch, e. d., wendel,antineoplastic agents, mitoxantrone and the nonhydroxylated analog, ametantrone, were found to inhibit hepatic microsomal cytochrome /M50-dependent drug metabolism in vitro and in vivo....
Synthesis and tau rna binding evaluation of ametantrone-containing ligandsWe describe the synthesis and characterization of ametantrone-containing RNA ligands based on the derivatization of this intercalator with two neamine moieties (Amt-Nea,Nea) or with one azaquinolone heterocycle and one neamine...
Synthesis and tau rna bindingevaluation of ametantrone-containingligandsWedescribe the synthesis and characterization of ametantrone-containingRNA ligands based on the derivatization of this intercalator withtwo neamine moieties (Amt-Nea,Nea) or with one azaquinolone heterocycleand one neamine (Amt-Nea,Azq)...
